IMDIK - researcher assistant or assistant professor recrutation

IMDIK

Job Vacancy is announced

by the Director of Mossakowski Medical Research Institute, Polish Academy of Sciences

for the position of

 

Post-doctoral Research Assistant or Post-doctoral Assistant Professor*

 

 

Recruitment is related to the project: “Deciphering the effect of PGC1a on mitochondrial biogenesis and neural differentiation during early development of human cerebral organoids”, OPUS 18, no. 2019/35/B/NZ3/04383, funded by The National Science Centre, Poland inDepartment of Stem Cell Bioengineering, Mossakowski Medical Research Institute Polish Academy of Sciences.

 

 

City: Warsaw

Scientific discipline: medical sciences

Announcement date:  September 17th, 2021

Application deadline: October 1st, 2021

Expected date of the interview: the first half of October 2021

Expected date of competition results announcement: the second half of October 2021

Expected date of taking the position: November 2021 (The job starting date may change depending on the regulations related to COVID-19 epidemy)

Link to page: http://www.imdik.pan.pl

Key words: post-doc, assistant, assistant professor, brain organoids, mitochondrial biogenesis, neural differentiation,  transcriptomic analysis.

 

* Depending on the assessment of the candidate's qualifications, the Recruitment Committee may recommend employment as an assistant or assistant professor.

 

The area of the research in which the candidate would participate:

The main project objective is to identify an unravel molecular mechanisms of the cross-talk between mitochondria and neural fate commitment during development of human cerebral organoids. Our group has previously proved important role of mitochondrial biogenesis in neural stem cells fate specification. Accordingly, in our experiments neuronal to glial switch along differentiation of human induced Pluripotent Stem Cells (iPSC) correlated with upregulation of PPARGC1A gene expression (encoding PGC-1α, positive master regulator of mitochondrial biogenesis). In this project we aim to verify hypothesis, that developmental stage-dependent neural fate specification in human cerebral organoids is regulated by PGC-1α pathway and is linked to the mitochondrial biogenesis.

Generation of human cerebral organoids from iPSC is a novel field of research with tremendous potential for basic science research as well as for diagnostic and therapeutic use. Human stem cells derived cerebral organoids provide a tractable, alternative model system of the early neural development, that is responsive to pharmacological and genetic manipulations, not possible in humans. Post-Doc will have possibility to contribute to the project using cutting–edge technologies: development of cerebral organoids from iPSC, gene editing, optogenetics, live confocal imaging as well as bioinformatics with large scale datasets. Title of project task: “Transcriptomic assessment and live cell imaging analysis of human cerebral organoids to reveal common and unique patterns of developmental trajectories upon stimulation of mitochondrial biogenesis”.

 

Necessary Requirements:

  • PhD degree in biological sciences, medical sciences, pharmacy, veterinary, or related sciences,
  • experience in laboratory techniques in biochemistry, molecular biology (e.g. isolation of DNA, RNA, proteins and small molecule compounds, western blot; qPCR; immunohistochemistry; spectrophotometric/fluorometric techniques),
  • experience in planning and conducting in vitro procedures,
  • ability to analyze data and competence in statistical methods used in scientific research,
  • bioinformatic competence to work with raw and processed large scale omics data (e.g. RNA-seq, exome-seq, proteomics, metabolomics), in silico molecular pathway analysis, systems biology, biostatistics,
  • documented scientific achievements including publications in journals from JCR list,
  • participation in scientific conferences and internships,
  • working knowledge of statistical software (e.g. GraphPad Prism, SPSS, R, Statistica),
  • ability to work in a team and independently,
  • excellent knowledge of English, allowing effective communication and preparation of scientific manuscripts,
  • indication of Mossakowski Medical Research Institute Polish Academy of Sciences as a first place of employment.

 

Desirable Requirements:

  • experience in working with stem cells cultures,
  • knowledge of modern omics research techniques (ATAC-seq, ChIP-seq, scRNAseq),
  • knowledge of genome editing methods.

 

Description of duties:

  • carrying out research, formulating biological hypothesis,
  • planning and performing in vitro experiments, using cell culture methods,
  • implementing biochemistry, molecular biology and imaging methods (light and confocal microscopy),
  • analyzing the experimental data,
  • presenting the results at seminars within the Institute and at scientific forum, including international conferences,
  • preparation of scientific publications,
  • implementing new research technologies and establishing cooperation with external entities.

 

We offer:

  • Full-time employment contract for the project,
  • Opportunity to work in the friendly environment of experienced research team,
  • Scientific cooperation with other research centers in Poland and abroad,
  • Opportunity to participate and present obtained results at international conferences,
  • Substantive and administrative support in accessing scholarships and grants.

 

How to Apply

 

Documents should be sent to e-mail: buzanskaTen adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.andTen adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.

Application Deadline:  October 1st, 2021

Please include the reference number (ZBKM-111-2/2021) in your correspondence.

 

Required documents:

  • motivation letter with description of candidate’s scientific interests, scientific work, scientific independency, participation in publications and research grants,
  • CV listing candidate’s education, professional experience, scientific achievements, authored or co-authored publications and conference abstracts, internships and training,
  • copy of the PhD (or equivalent) diploma,
  • references (optionally).

 

For more information about the project, please contact with Prof. dr hab. Leonora Bużańska, Leader of the project,
e-mail: Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.

 

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